Project 14

Biouterus–bioengineering an in vitro uterine model for investigation of maternal-embryo communication

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Host Institution:

Univ. Collegue Dublin (Dublin, Ireland)

Supervisors: Dr Patrick Lonergan

Co-supervisors: Dr. Jon Romero Aguirregomezcorta | Dr. Dimitrios Rizos

Non-academic mentor: Dr. Jon Romero

Institution of enrolment:

Other institutions involved/secondments:

Enrolment in Doctoral degrees: UCD (Reproductive Biology)-UMU (Biology and Technology of Reproductive Health)

OBJECTIVES

Develop a 3D culture system in vitro to support conceptus development based on knowledge of changes in uterine lumen fluid composition between Days 12-16 and changes in conceptus metabolism during this period.
To create an atlas of spatiotemporal transcriptomic and morphological changes occurring during gastrulation in cattle will serve as a primary basis for biological interpretation and functional validation of other models to interrogate the causes of embryonic loss, to develop/refine in vitro models of gastrulation and to establish strategies to improve fertility.