Projects

Project 15

Identification of biomarkers for implantation secreted by human embryos and their effect on human endometrial cells

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Host Institution:
Univ. Gent (Gent, Belgium)

Doctoral Candidate: Haitao Li

Supervisors: Dr. Ann Van Soom

Co-supervisors: Dr. Nicola Bernabo | Dr. Laurent Galio

Non-academic mentor: Dr. Tomasso Guazzini

Institution of enrolment:
University of Gent-UGENT
Other institutions involved/secondments:
University of Teramo-UNITE (Italy)
INRAE-Jouy-en-Josas
Laboratorio Materiali Polimerici Ecocompatibili-LMP

Enrolment in Doctoral degrees: UGENT (Life sciences)-UNITE (Cellular and Molecular Biotechnologies)

OBJECTIVES

  1. Collection of EVs from medium conditioned by human embryos that either gave rise to a pregnancy/offspring or not.
  2. Identification of miRNAs and proteins differentially expressed in EVs from implanted and non-implanted human embryos.
  3. Uptake assessment of EVs from implanted and non-implanted embryos in an in vitro implantation model (endometrial cells and cell line St-T1b).
  4. Analyse by transcriptomics of endometrial cell lines if exposure to EVs or EV-derived miRNAs from implanted and non-implanted embryos impact differentially gene expression