Project 12

Realization of a 3d biomimetic device for improving in vitro fertilization and early embryo development

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Host Institution:

Univ. Teramo (Teramo, Italy)

Supervisors: Dr. Nicola Bernabo

Co-supervisors: Dr. Pilar Coy | Dr. Tomasso Guazzini

Institution of enrolment:

Other institutions involved/secondments:

Enrolment in Doctoral degrees: UNITE (Cellular and Molecular Biotechnologies)-UMU (Biology and Technology of Reproductive Health)

OBJECTIVES

To design an innovative, biomimetic device for IVF and early embryo development.
To synthesize and test biomaterials suitable for the realization of the 3D scaffold for culture of oviductal cells and embryo development.
To improve IVF outcome using the device, either in terms of IVF outcome and embryo quality and reduction of epigenetic risk (mouse, bovine, and swine models).
To obtain an organ-on-chip system (HLM) to culture oviductal epithelial cells for multiple purposes (study of effects of endocrine disruptors and/or immune systems on fertilization) (mouse, bovine, swine as animal models and human).