Project 11

Antioxidant molecules role in art and ovarian aging prevention

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Host Institution:

Univ. Teramo (Teramo, Italy)

Supervisors: Dr. Barbara Barboni

Co-supervisors: Dr. Sebastian Canovas | Dr. Oliva Alberti |

Institution of enrolment:

Other institutions involved/secondments:

Enrolment in Doctoral degrees: UNITE (Cellular and Molecular Biotechnologies)-UMU (Biology and Technology of Reproductive Health)

OBJECTIVES

To develop proof of concept of anti-aging effect of antioxidant molecules on folliculogenesis and oogenesis in sheep.
To test the efficiency of antioxidant molecules in maintaining ovarian longevity in mice exposed to diet with high concentrations of NEFA.
To improve IVM/IVF technology outcomes by increasing oocyte/embryo quality through the in vivo preventive use of antioxidant molecules in mice exposed to a high NEFA diet regime.
To establish molecular markers of ovarian oxidative damage.