Project 1

Human sperm cryopreservation as an alternative for the decline of sperm quality with aging

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Host Institution:

IVI-MURCIA (Murcia, Spain)

Doctoral Candidate: Peter Silke

Supervisor: Dr. Juan Carlos Martínez

Co-supervisors: Dr. Carmen Matás | Dr. Nicola Bernabo

Institution of enrolment:

Other institutions involved/secondments:

Enrolment in Doctoral degrees: UMU (Biology and Technology of Reproductive Health)-UNITE (Cellular and Molecular Biotechnologies)

OBJECTIVES

To evaluate the impact of human aging in genetic and epigenetic signature of human sperm from patients <40 years old vs > 45 years old.
To analize if human sperm cryopreservation (slow freezing vs vitrification) could be useful to circumvent the decline of sperm quality by aging.
To predict an individual’s age based on molecular markers as sperm DNA methylation signatures and telomerase length.
To analyse the impact of age in human sperm selected ncRNAs, based on results from R2 in mouse.
To assess if the use of human sperm ncRNAs as molecular markers has complementary clinical value for assessment of fertility evaluation.